ペンシルバニア大のErfei Bi博士 ポスドク募集
The Bi lab is seeking two postdocs to study the mechanisms of cytokinesis using both budding yeast and mammalian cell models. One postdoc will work on yeast projects while the other will work on mammalian projects. Our overall goal is to determine the architecture, regulation, and function of the actomyosin ring and its coordination with targeted membrane deposition and localized ECM remodeling (or septum formation in yeast) during cytokinesis. Mechanistic questions will be addressed using an integrative approach that combines genetics, quantitative live‑cell imaging, cutting‑edge EM, and biochemistry. Highly motivated individuals with a Ph.D. in biological sciences are welcome to apply. Preference will be given to those with experience in yeast or mammalian cell‑culture system, quantitative live‑cell imaging, and biochemistry. Stipends will be paid according to the NIH guideline (http://grants.nih.gov/grants/guide/notice-files/NOT-OD-15-048.html). The positions are renewable up to 4 years, depending on performance.
To apply, please send your CV, a short summary of your current research, and arrange two letters of recommendation sent to Dr. Erfei Bi (email@example.com; Tel: 215-573-6676), Professor of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104-6058. You can also learn more about our research by reading some of our recent papers:
1. Oh, Y., and E. Bi. 2011. Septin structure and function in yeast and beyond. Trends Cell Biol. 21:141-148.
2. Oh, Y., K.J. Chang, P. Orlean, C. Wloka, R. Deshaies, and E. Bi. 2012. Mitotic exit kinase Dbf2 directly phosphorylates chitin synthase Chs2 to regulate cytokinesis in budding yeast. Mol. Biol. Cell 23:2445-2456.
3. Bi, E.,* and H.‑O. Park. 2012. Cell polarization and cytokinesis in budding yeast. Genetics 191:347‑387 (the article will also appear as a chapter in YeastBook) (*corresponding author).
4. Wloka, C., E.A. Vallen, L. Thé, X. Fang, and E. Bi. 2013. Immobile myosin‑II plays a scaffolding role during cytokinesis in budding yeast. J. Cell Biol. 200:271‑286. (Highlighted in Biosights with a podcast entitled “Erecting a scaffold for cytokinesis”).
5. Okada, S.a, M. Ledaa, J. Hanna, N.S. Savage, E. Bib, and A. Goryachevb. 2013. Daughter cell identity emerges from the interplay of Cdc42, septins, and exocytosis. Dev. Cell: 26:148-161 (Cover story for the July 28th 2013 issue, with a commentary entitled "Bud building by septin patch hole punching") (aco‑first authors; bco‑corresponding authors. Authors from my lab are underlined).
6. Wang T, Yanger K, Stanger BZ, Cassio D, Bi E. 2014. Cytokinesis defines a spatial landmark for hepatocyte polarization and apical lumen formation. J. Cell Sci. 127:2483‑92 (Highlighted on the cover and also in “In this issue” with a piece entitled “Cytokinesis links polarization and tube formation in liver”).
7. Ong K, Wloka C, Okada S, Svitkina T*, Bi E*. 2014. Architecture and dynamic remodeling of the septin cytoskeleton during the cell cycle. Nature Communications. Dec 5;5:5698. doi: 10.1038/ncomms6698. (*co‑corresponding author)
[ 15.07.22 ]